Thomas Günther Pomorski

A single vesicle fluorescence microscopy platform to quantify phospholipid scrambling

The paper introduces a single vesicle fluorescence microscopy platform to quantify phospholipid scrambling by VDAC1 dimers and opsin, revealing kinetic heterogeneity in scrambling rates.

Long-term single-molecule Ca2+ flux recordings reveal mode-switching regulation of Ca2+-ATPases

This study uses single-molecule recordings to show Ca2+-ATPases switch between active and inactive modes, revealing a new regulatory mechanism for Ca2+ homeostasis.

Revisiting flippase specificity: Drs2-Cdc50 transports multiple anionic lipid substrates

The paper shows that the Drs2-Cdc50 flippase complex transports multiple anionic lipids, not just phosphatidylserine, and identifies the role of the water network in substrate recognition.

Sterols govern membrane susceptibility to saponin-induced lysis

This study shows that different sterol classes affect saponin-induced membrane lysis, with zoosterols and mycosterols increasing susceptibility while phytosterols provide resistance.

Trans-Translation inhibitors and copper ions synergize for enhanced antibiotic activity

This paper shows that trans-translation inhibitors KKL-40 and KKL-55 synergize with copper ions to enhance antibacterial activity against B. subtilis by causing rapid translation stalling and preventing copper toxicity response.

HOCl Forms Lipid N-Chloramines in Cell Membranes of Bacteria and Immune Cells

The paper shows HOCl forms lipid N-chloramines in bacterial and immune cell membranes, which oxidize proteins and are neutralized by glutathione, suggesting a role in inflammation and immune response.