Sascha Heinrich

This study identifies two selective peptide deformylase inhibitors with antibacterial activity and low cytotoxicity, validated through in vitro and in vivo assays.

This paper shows that trans-translation inhibitors KKL-40 and KKL-55 synergize with copper ions to enhance antibacterial activity against B. subtilis by causing rapid translation stalling and preventing copper toxicity response.

The paper shows HOCl forms lipid N-chloramines in bacterial and immune cell membranes, which oxidize proteins and are neutralized by glutathione, suggesting a role in inflammation and immune response.