Detection of a historic reservoir of bedaquiline / clofazimine resistance associated variants in Mycobacterium tuberculosis
Camus Nimmo, Arturo Torres Ortiz, Juanita Pang, Mislav Acman, Cedric C.S. Tan, James Millard, Nesri Padayatchi, Alison D. Grant, Max R. O’Donnell, Alexander S. Pym, Ola Brønstad Brynildsrud, Vegard Eldholm, Louis Grandjean, Xavier Didelot, François Balloux, Lucy van Dorp
The paper identifies pre-existing bedaquiline resistance variants in Mycobacterium tuberculosis genomes before clinical use of the drug, highlighting the need for rapid susceptibility testing.
bioRxiv · Oct 6, 2020 · PreprintGenomics