Claudia Chica

Stress-responsive Mycobacterium tuberculosis subpopulations manipulate macrophage polarization and can be targeted to limit inflammation

The paper identifies stress-responsive Mycobacterium tuberculosis subpopulations that influence macrophage polarization and shows targeting GroEL2 can limit inflammation.

NK cells undergo transcriptional and functional reprogramming following Streptococcus pneumoniae infection

This study uses single-cell RNA-seq to show that NK cells reprogram transcriptionally and functionally after Streptococcus pneumoniae infection, revealing new roles in bacterial immunity.

The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity

The paper identifies an epigenetic mechanism in bronchial epithelial cells that enables trained immunity through chromatin remodeling and gene expression changes following flagellin exposure.

SCHNAPPs - Single Cell sHiNy APPlication(s)

SCHNAPPs is a Shiny-based tool for bench-scientists to analyze scRNA-seq data, offering quality control, clustering, differential expression, and visualization with reproducible reporting.

Epigenomic signature of the progeroid Cockayne syndrome exposes distinct and common features with physiological ageing

The paper identifies an epigenetic signature in Cockayne syndrome fibroblasts, showing similarities to normal aging and differences from other progeroid diseases.

ChIPflow:from raw data to epigenomic dynamics

ChIPflow is a pipeline for epigenomic data analysis from raw data to differential analysis, showing that statistical settings affect results depending on chromatin factor dynamics and variability.