Mohamad-Ali Fawal

Acute dietary methionine restriction highlights sensitivity of neocortex development to metabolic variations

This study shows that acute methionine restriction during mouse neocortex development severely reduces growth and neuronal production, but this effect is reversible with dietary recovery.

DHFR metabolic activity controls neurogenic transitions in the developing Human and mouse neocortex

This study shows that reducing DHFR activity in neural progenitors accelerates indirect neurogenesis and alters neuronal composition in human and mouse neocortex.

Ephrin-B2 paces neuronal production in the developing neocortex

This study shows ephrin-B2 regulates the timing and number of neuronal production in the developing neocortex through juxtacrine signaling on neural progenitors.

Population dynamics and neuronal polyploidy in the developing neocortex

The paper quantifies progenitor and neuronal populations during mouse neocortex development and identifies polyploid neurons.

Crosstalk between one carbon metabolism and eph signaling promotes neural stem cells differentiation through epigenetic remodeling

The paper shows that Eph-B signaling affects 1C metabolism in neural stem cells, altering H3K4 methylation and promoting differentiation.