Laurent Le Cam

This study shows E4F1 regulates melanogenesis in mice by controlling protein translation and MITF expression through the ISR pathway.

This study shows that androgen receptor signaling regulates beige adipocyte remodeling, mitochondrial function, and metabolic adaptation in male mice.

This study evaluates bulk ATAC-seq's ability to detect genomic variants, CNVs, and telomere repeats, showing its potential as an integrative tool for cancer research.

This study shows that acute methionine restriction during mouse neocortex development severely reduces growth and neuronal production, but this effect is reversible with dietary recovery.

The paper develops a data-driven mechanistic model to quantify hypoxia profiles in tumors using reaction-diffusion equations and vascular data.

This paper develops a computational model to predict outcomes of different therapeutic strategies in melanoma by analyzing single-cell mRNA sequencing data and simulating tumor heterogeneity and drug resistance.

This paper introduces DEXOM, a method to enumerate diverse optimal metabolic networks from multi-omics data to improve in-silico gene essentiality predictions in yeast.