Polypyrimidine Tract Binding Protein blocks microRNA-124 biogenesis to enforce its neuronal specific expression.
Kyu‐Hyeon Yeom, Simon A. Mitchell, Anthony J. Linares, Sika Zheng, Chia-Ho Lin, Xiaojun Wang, Alexander Hoffmann, Douglas L. Black
The paper shows PTBP1 inhibits miR-124 biogenesis in mESCs, creating a regulatory loop that reinforces neuronal differentiation.
bioRxiv · Apr 8, 2018 · PreprintMolecular Biology