Chia-Ho Lin

This study identifies RBM5's role in regulating splicing by activating DHX15 and blocking spliceosome progression, with implications for cancer-related splicing dysregulation.

This study shows that the SF3B1 K700E mutation causes widespread changes in U2/branchpoint recognition without altering 3' splice site selection.

The paper identifies a non-coding risk variant in GBA1 associated with Parkinson's disease in African ancestry populations, showing it disrupts splicing and reduces glucocerebrosidase activity.

This study identifies multi-part RNA regulatory modules recognized by the Rbfox1/LASR complex and shows how these modules regulate alternative pre-mRNA splicing.

The paper shows that alternative splicing of DPF2, regulated by PTBP1, affects chromatin organization and transcriptional regulation during stem cell maintenance and neuronal differentiation.

The paper identifies RBM5 and RBM10 as U2 snRNP subunits that interact with intron branch sites and regulate splicing by acting as silencers.

The paper shows Malat1 is a cytoplasmic coding RNA in neurons that modulates synaptic function through local translation of a small peptide.

This study examines how aging affects the transcriptome and chromatin accessibility in male and female mouse hippocampus, identifying sex-specific changes in gene expression, alternative splicing, and chromatin features.

The paper introduces an improved FISH probe labeling method that enables high-purity, low-cost probes with high labeling efficiency, applied to visualize retained introns in cells.

The paper shows PTBP1 inhibits miR-124 biogenesis in mESCs, creating a regulatory loop that reinforces neuronal differentiation.