Sika Zheng

This study identifies conserved alternative splicing events associated with maximum lifespan across mammals, showing distinct patterns in the brain compared to peripheral tissues.

This study shows that PTBP1 depletion in astrocytes causes unique splicing changes without neuronal features, suggesting PTBP1 alone is insufficient for neuronal reprogramming.

Shiba and scShiba systematically identify differential RNA splicing across RNA-seq platforms with high accuracy and low false positives, even with small sample sizes.

This study shows that deleting Ptbp1 in adult retinal Muller glia and brain astrocytes does not convert glia into neurons, using genetic lineage tracing, scRNA-Seq, and electrophysiology.

The paper shows that Xist RNA forms a protein condensate with binding proteins to establish the Xi-compartment and maintain gene silencing.

The paper shows PTBP1 inhibits miR-124 biogenesis in mESCs, creating a regulatory loop that reinforces neuronal differentiation.