Kyu‐Hyeon Yeom

Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation

The paper shows that alternative splicing of DPF2, regulated by PTBP1, affects chromatin organization and transcriptional regulation during stem cell maintenance and neuronal differentiation.

The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons.

The paper shows Malat1 is a cytoplasmic coding RNA in neurons that modulates synaptic function through local translation of a small peptide.

Improved enzymatic labeling of fluorescent in situ hybridization probes applied to the visualization of retained introns in cells

The paper introduces an improved FISH probe labeling method that enables high-purity, low-cost probes with high labeling efficiency, applied to visualize retained introns in cells.

Tracking pre-mRNA maturation across subcellular compartments identifies developmental gene regulation through intron retention and nuclear anchoring.

Polypyrimidine Tract Binding Protein blocks microRNA-124 biogenesis to enforce its neuronal specific expression.

The paper shows PTBP1 inhibits miR-124 biogenesis in mESCs, creating a regulatory loop that reinforces neuronal differentiation.