Molecular BiologybioRxivPreprint
A B1 SINE element within the mouse Malat1 long noncoding RNA acts as an internal ribosome entry site mediating micropeptide translation
1 citation
Author
Douglas L. Black
University of California, Los AngelesORCID 0000-0002-2705-8187Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2018-2026 · peak 6/yrCo-Author Collaboration Network
10 top collaborators · 24 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship15 papers
Recent·Most cited
- Synthetic BiologyNature NanotechnologyPeer-reviewed
Programmable artificial RNA condensates in mammalian cells
Shiyi Li, Yuna Kim, Kevin Wang…·Elisa Franco
This paper introduces programmable artificial RNA condensates in mammalian cells that can be controlled for subcellular localization and molecular recruitment.
12 citationstop 1% - Molecular BiologybioRxivPreprint
The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing
Z. Hong Zhou, Shiheng Liu, Tiantian Su…·Andrey Damianov
This study identifies RBM5's role in regulating splicing by activating DHX15 and blocking spliceosome progression, with implications for cancer-related splicing dysregulation.
- Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewed
Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing.
Andrey Damianov, Chia-Ho Lin, Jian Zhang…·Douglas L. Black
This study shows that the SF3B1 K700E mutation causes widespread changes in U2/branchpoint recognition without altering 3' splice site selection.
10 citations - Genetic & Genomic MedicineNature Structural & Molecular BiologyPeer-reviewed
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
Pilar Álvarez Jerez, Peter Wild Crea, Daniel M. Ramos…·Cornelis Blauwendraat
The paper identifies a non-coding risk variant in GBA1 associated with Parkinson's disease in African ancestry populations, showing it disrupts splicing and reduces glucocerebrosidase activity.
23 citationstop 2% - Molecular BiologybioRxivPreprint
The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multi-part RNA regulatory modules
Parham Peyda, Chia-Ho Lin, Kelechi Onwuzurike, Douglas L. Black
This study identifies multi-part RNA regulatory modules recognized by the Rbfox1/LASR complex and shows how these modules regulate alternative pre-mRNA splicing.
10 citations - Molecular BiologyCell stem cellPeer-reviewed
Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation
Mohammad Nazim, Chia-Ho Lin, An‐Chieh Feng…·Douglas L. Black
The paper shows that alternative splicing of DPF2, regulated by PTBP1, affects chromatin organization and transcriptional regulation during stem cell maintenance and neuronal differentiation.
34 citationstop 3% - Molecular BiologyMolecular CellPeer-reviewed
The apoptotic splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin
Andrey Damianov, Chia-Ho Lin, Jeffrey T.-J. Huang…·Douglas L. Black
The paper identifies RBM5 and RBM10 as U2 snRNP subunits that interact with intron branch sites and regulate splicing by acting as silencers.
32 citationstop 4% - Molecular BiologybioRxiv
The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons.
Wen Xiao, Reem Halabi, Chia-Ho Lin…·Douglas L. Black
The paper shows Malat1 is a cytoplasmic coding RNA in neurons that modulates synaptic function through local translation of a small peptide.
42 citations - NeuroscienceFrontiers in Molecular NeurosciencePeer-reviewed
Aging Differentially Alters the Transcriptome and Landscape of Chromatin Accessibility in the Male and Female Mouse Hippocampus
Jennifer M. Achiro, Yang Tao, Fuying Gao…·Kelsey C. Martin
This study examines how aging affects the transcriptome and chromatin accessibility in male and female mouse hippocampus, identifying sex-specific changes in gene expression, alternative splicing, and chromatin features.
- Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewed
The RNA binding proteins hnRNP H and F regulate splicing of a MYC dependent HRAS exon in Prostate Cancer Cells
Xinyuan Chen, Harry Taegyun Yang, Beatrice D. Zhang…·Douglas L. Black
The paper identifies hnRNP H and F as regulators of Myc-dependent HRAS exon splicing in prostate cancer, showing their roles in splicing activation and correlation with Myc hallmarks.
35 citationstop 5% - Molecular BiologyRNAPeer-reviewed
Improved enzymatic labeling of fluorescent in situ hybridization probes applied to the visualization of retained introns in cells
Wen Xiao, Kyu‐Hyeon Yeom, Chia-Ho Lin, Douglas L. Black
The paper introduces an improved FISH probe labeling method that enables high-purity, low-cost probes with high labeling efficiency, applied to visualize retained introns in cells.
- Molecular BiologybioRxiv
Tracking pre-mRNA maturation across subcellular compartments identifies developmental gene regulation through intron retention and nuclear anchoring.
51 citations - Molecular BiologyNaturePeer-reviewed
An Xist-dependent protein assembly mediates Xist localization and gene silencing
Amy Pandya‐Jones, Yolanda Markaki, Jacques Serizay…·Kathrin Plath
The paper shows that Xist RNA forms a protein condensate with binding proteins to establish the Xi-compartment and maintain gene silencing.
- Molecular BiologybioRxivPreprint
Polypyrimidine Tract Binding Protein blocks microRNA-124 biogenesis to enforce its neuronal specific expression.
Kyu‐Hyeon Yeom, Simon A. Mitchell, Anthony J. Linares…·Douglas L. Black
The paper shows PTBP1 inhibits miR-124 biogenesis in mESCs, creating a regulatory loop that reinforces neuronal differentiation.
1 citation