Author

Kacey N. Mersch

Washington University in St. LouisORCID 0000-0002-2497-1800Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

Binh NguyeniD· 2 shared Timothy M. LohmaniD· 2 shared Alexander G. KozloviD· 1 shared Ankita ChaddaiD· 1 shared Eric A. GalburtiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersBiophysics

Binh NguyenORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintAug 7, 2026

Two heads are better than one: Single stranded DNA translocation of UvrD-family dimers vs. monomers

Kacey N. Mersch, Binh Nguyen, Alexander G. Kozlov, Timothy M. Lohman

This study compares ssDNA translocation and helicase activities of covalent dimers and monomers of E. coli UvrD, showing higher processivity and DNA unwinding in dimers.

DOI 10.64898/2026.08.07.743547

E. coliDNA methylation

𝕏 PostBluesky

BiochemistryNucleic Acids ResearchPeer-reviewedJul 3, 2026

A Conserved Mechanism for Dimerization and Activation of Superfamily 1A UvrD-family Helicases

Binh Nguyen, Kacey N. Mersch, Ankita Chadda…·Timothy M. Lohman

This study identifies a conserved dimerization mechanism in SF1A UvrD-family helicases, showing that the 2B domain mediates dimerization and activation across multiple species.

2 citations

E. colimouse

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