Author

Graham E. Little

Université de SherbrookeORCID 0000-0002-2511-6945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:imaging· 2 Organism:mouse· 2 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1 Assay:multiome· 1 Approach:statistical model· 1

Frequent Co-Authors

Alison Jane CantyiD· 1 shared Antonio TrabalzaiD· 1 shared Arnaud BoréiD· 1 shared Charles PoirieriD· 1 shared Cher BassiD· 1 shared Christian BeaulieuiD· 1 shared Jesus Alejandro Acosta‐FrancoiD· 1 shared Johanna JacksoniD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperNeuroscience

Alison Jane CantyORCID

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Author profile →

4 papers

Recent·Most cited

Automated Surface-Based Segmentation of Deep Gray Matter Regions Based on Diffusion Tensor Images Reveals Unique Age Trajectories Over the Healthy Lifespan

Graham E. Little, Jesus Alejandro Acosta‐Franco, Christian Beaulieu

This paper introduces an automated DTI-only segmentation method for deep gray matter regions, revealing distinct age-related changes in volume, FA, and MD that differ from volumetric trajectories.

NMR in Biomedicine · Jul 9, 2026Peer-reviewedNeuroscience

Mapping caudolenticular gray matter bridges in the human brain striatum through diffusion magnetic resonance imaging and tractography

Graham E. Little, Charles Poirier, Arnaud Boré, Martin Parent, Laurent Petit, Maxime Descoteaux

This study introduces a novel tractography method to reconstruct and analyze caudolenticular gray matter bridges in the human brain using diffusion MRI, demonstrating their microstructural properties.

Human Brain Mapping · Jun 1, 2025Peer-reviewedNeuroscience

Single-axon-resolution intravital imaging reveals a rapid onset form of Wallerian degeneration in the adult neocortex

Alison Jane Canty, Johanna Jackson, Lieven Huang, Antonio Trabalza, Cher Bass, Graham E. Little, Vincenzo De Paola

The paper uses intravital imaging to show that injured cortical axons undergo a rapid-onset form of Wallerian degeneration (ROWD) that differs from classic Wallerian degeneration in onset timing, speed, and dependency on synaptic density.

bioRxiv · Aug 14, 2018 · PreprintNeuroscience

Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance

Manuela D. Mitsogiannis, Graham E. Little, Kevin J. Mitchell

This study investigates the role of Semaphorin-6A-Plexin-A2/Plexin-A4 signaling in thalamocortical axon guidance and subpallial development in mice.

Neural Development · Apr 24, 2017Peer-reviewedNeuroscience