Vincenzo De Paola

The paper constructs a single-cell atlas of fetal Down syndrome cortex, identifying chromosome 21 transcription factors that regulate intellectual disability gene networks and showing their normalization can restore molecular signatures.

This study investigates age-related changes in axon regeneration and synaptic dynamics in the injured aged mammalian cortex, finding impaired regeneration and increased synaptic reorganization.

The paper shows that cohesin's role in neuronal gene expression depends on chromatin loop length, with longer loops requiring cohesin for full gene expression.

The paper uses intravital imaging to show that injured cortical axons undergo a rapid-onset form of Wallerian degeneration (ROWD) that differs from classic Wallerian degeneration in onset timing, speed, and dependency on synaptic density.