Johanna Jackson

Neuronal and glial transcriptional states vary with proximity to tangle-bearing neurons in the human entorhinal cortex

The paper examines how proximity to tangle-bearing neurons affects transcriptional states in human entorhinal cortex cells, finding that nearby neurons and glia show distinct molecular signatures related to disease.

Stage-specific proteomic signatures of synaptopathy in Alzheimers disease

The paper identifies stage-specific synaptic proteomic signatures in Alzheimer's disease and links them to plasma proteins associated with disease progression and cognitive decline.

A synaptic-astrocytic proteomic signature associated with synaptopathy in Alzheimer's Disease

This study identifies a synaptic-astrocytic proteomic signature associated with synapse loss in Alzheimer's Disease across different disease stages.

Single-cell Mendelian randomisation identifies cell-type specific genetic effects on human brain disease and behaviour

The paper uses single-cell Mendelian randomisation to identify cell-type specific genetic effects on brain disease and behaviour, revealing 118 genes with causal associations to 16 brain phenotypes.

Single nuclear transcriptional signatures of dysfunctional brain vascular homeostasis in Alzheimer's disease

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

Omix: A Multi-Omics Integration Pipeline

Omix integrates and analyzes multi-omics data to generate pseudo-temporal profiles in Alzheimer's Disease using bulk proteomics and transcriptomics datasets.

Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy

This study tracks synapse plasticity in tauopathy and finds that changes in synaptic structure precede neurite degeneration, with distinct patterns in axons and dendrites.

Imbalance in the response of pre- and post-synaptic components to amyloidopathy

The paper examines how Aβ plaques develop and affect synaptic density and turnover in a mouse model of Alzheimer's disease, finding an imbalance in pre- and post-synaptic responses.

Single-axon-resolution intravital imaging reveals a rapid onset form of Wallerian degeneration in the adult neocortex

The paper uses intravital imaging to show that injured cortical axons undergo a rapid-onset form of Wallerian degeneration (ROWD) that differs from classic Wallerian degeneration in onset timing, speed, and dependency on synaptic density.