Martin Parent

WDR44 drives de novo α-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson's Disease

This study identifies WDR44 as a driver of de novo α-synuclein aggregation at the lysosomal membrane, linking early aggregation events to neuronal dysfunction in Parkinson's Disease.

CRISPR/CAS9-MEDIATED LOSS OF VESICULAR GLUTAMATE TRANSPORTER IN SEROTONIN NEURONS OF THE DORSAL RAPHE NUCLEUS LEADS TO SYNAPTIC CHANGES AND ANXIETY-LIKE BEHAVIORS

This study investigates the role of VGluT3 in DRN 5-HT neurons by manipulating its expression and assesses effects on synaptic structure and behavior.

Parkinson's disease risk factors are expressed at brain barriers.

This study identifies Parkinson's disease risk genes expressed at brain barriers and shows poor transcript-protein correlation and low interspecies conservation.

Modulation of SLP-2 expression protects against alpha-synuclein neuropathology by mitigating mitochondrial dysfunction

This study shows that increasing SLP-2 levels reduces alpha-synuclein-induced mitochondrial damage and neurodegeneration in Parkinson's disease models.

Mapping caudolenticular gray matter bridges in the human brain striatum through diffusion magnetic resonance imaging and tractography

This study introduces a novel tractography method to reconstruct and analyze caudolenticular gray matter bridges in the human brain using diffusion MRI, demonstrating their microstructural properties.

Integrated stress response associated with dark microglia promotes microglial lipogenesis and contributes to neurodegeneration

The paper identifies a neurodegenerative microglia phenotype driven by the integrated stress response (ISR) and shows that inhibiting ISR ameliorates neurodegenerative pathologies in AD models.

Virally encoded single-chain antibody fragments targeting alpha-synuclein protect against motor impairments and neuropathology in a mouse model of synucleinopathy

Neurexins Regulate GABA Co-release by Dopamine Neurons

This study shows that neurexins regulate dopamine neuron connectivity and neurotransmission by affecting dopamine reuptake and GABA co-release.

Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals

This study shows dopaminergic neurons form a unique axonal arbor with mostly non-synaptic terminals, expressing exocytosis proteins and being active, and highlights the role of specific proteins in synapse formation.

MICRA-Net: MICRoscopy Analysis Neural Network to solve detection, classification, and segmentation from a single simple auxiliary task

MICRA-Net is a weakly-supervised neural network that uses a simple classification task to perform segmentation, detection, and enumeration on microscopy images with limited annotated data.

The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo

The paper shows that ATP/ADP levels and autophagy interact to regulate neuronal migration by controlling cell pausing and focal adhesion recycling in mice.

High sensitivity mapping of cortical dopamine D2 receptor expressing neurons

The paper identifies and maps D2 receptor expressing neurons in the adult mouse cortex using multimodal techniques, revealing previously uncharacterized clusters and heterogeneity in receptor expression.