Farid F. Kadyrov

Collateral Immune Cell Signaling Compromises the Efficacy of T-cell Engaging Therapies for Cardiac Fibrosis

This study shows that FAP-targeted BiTE(R) molecules, intended to reduce cardiac fibrosis, instead worsen heart function by triggering harmful immune responses.

Therapeutic Spp1 silencing in TREM2+ cardiac macrophages suppresses atrial fibrillation

This study shows that silencing Spp1 in TREM2+ cardiac macrophages reduces atrial fibrosis and suppresses AFib in mice, suggesting a new immunotherapy approach.

Defining Cardiac Recovery at Single Cell Resolution

The paper defines the cellular and transcriptional features of cardiac recovery using snRNA-seq, identifying RUNX1 downregulation as a key predictor and potential therapeutic target.