Wee Loong Chin

GeneInsight: Condensing Gene Set Knowledge via Language Models

GeneInsight synthesizes gene set annotations using topic modeling and language models to provide interpretable summaries that reveal biologically significant insights overlooked by traditional enrichment analyses.

Copper chelation reprograms the tumour microenvironment to enhance immune checkpoint blockade therapy in preclinical mesothelioma

This study shows copper chelation enhances immune checkpoint blockade therapy in mesothelioma by altering the tumour microenvironment and increasing cytotoxic lymphocytes.

Spectral detection of condition-specific biological pathways in single-cell gene expression data

CDR-g detects subtle condition-specific gene coexpression changes in single-cell data, identifying novel biological pathways and subpopulations not found by conventional differential expression analysis.