Copper chelation reprograms the tumour microenvironment to enhance immune checkpoint blockade therapy in preclinical mesothelioma
Kofi L. P. Stevens, Naomi Damstra, Claudia Peh, Nicola Principe, Amber‐Lee Phung, Joshua T. Ravensdale, Sophie Wu, Vu Vu Pham, Giulia Castrogiovanni, Louis Boon, Keea R. Inder-Smith, Wen-Shuz Yeow, Daryl L. Howard, Ramesh Ram, Abha Chopra, , Jonathan Chee
This study shows copper chelation enhances immune checkpoint blockade therapy in mesothelioma by altering the tumour microenvironment and increasing cytotoxic lymphocytes.
bioRxiv · Jul 30, 2026 · PreprintImmunology