Author

Xin Yuan

Beth Israel Deaconess Medical CenterORCID 0000-0002-2558-0203Unclaimed ORCID profile · follow to get notified of new preprints

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Xin Yuan6 papers · First Affiliated Hospital Zhejiang University

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Joshua W. RussoiD· 2 shared Mary‐Ellen TapliniD· 2 shared Steven P. BalkiD· 2 shared Abhay KanodiaiD· 1 shared Adam G. SowalskyiD· 1 shared Alex TokeriD· 1 shared Alice Bosma-Moody· 1 shared Alok K. TewariiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Joshua W. RussoORCID

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2 papers

Recent·Most cited

Cancer BiologyJournal of Clinical InvestigationPeer-reviewedOct 2, 2025

Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion

Fen Ma, Sen Chen, Luigi Giovanni Cecchi…·Steven P. Balk

This study shows that in prostate cancer with TMPRSS2:ERG fusion, androgen deprivation increases AKT activation, which may reduce the effectiveness of AR-targeted therapy, suggesting combination therapy could be beneficial.

4 citations

𝕏 PostBluesky

GenomicsNature MedicinePeer-reviewedMar 1, 2021

Transcriptional mediators of treatment resistance in lethal prostate cancer

Meng Xiao He, Michael S. Cuoco, Jett P. Crowdis…·Eliezer M. Van Allen

This study identifies transcriptional states in mCRPC that mediate treatment resistance, including AR splicing heterogeneity, TGF-β signaling, and immune infiltration patterns.

184 citationstop 1%

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