Author

Sen Chen

Beth Israel Deaconess Medical CenterORCID 0000-0002-5872-2597Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adam G. SowalskyiD· 1 shared Alex TokeriD· 1 shared Anson T. KuiD· 1 shared Betul Ersoy-FazliogluiD· 1 shared Carla CalaguaiD· 1 shared Changmeng CaiiD· 1 shared David Johnson EinsteiniD· 1 shared Fang XieiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Adam G. SowalskyORCID

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1 paper

Recent·Most cited

Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion

Fen Ma, Sen Chen, Luigi Giovanni Cecchi, Betul Ersoy-Fazlioglu, Joshua W. Russo, Seiji Arai, Seifeldin Awad, Carla Calagua, Fang Xie, Larysa Poluben, Olga S. Voznesensky, Anson T. Ku, Fatima H. Karzai, Changmeng Cai, David Johnson Einstein, , Steven P. Balk

This study shows that in prostate cancer with TMPRSS2:ERG fusion, androgen deprivation increases AKT activation, which may reduce the effectiveness of AR-targeted therapy, suggesting combination therapy could be beneficial.

Journal of Clinical Investigation · Oct 2, 2025Peer-reviewedCancer Biology