Leslie Myatt

This study examines senescence pathways in trophoblasts from GDM pregnancies, finding sexually dimorphic dysregulation of p21, p16-RB, and p53-Lamin A/C pathways affecting trophoblast function.

The paper examines how maternal obesity and gestational diabetes affect placental mitochondrial structure, dynamics, and clearance, finding sex-specific differences in mitochondrial function and quality control.

The paper examines lipidomic changes in maternal blood and placental tissue in obesity and gestational diabetes, revealing sexually dimorphic effects in placental fatty acid composition.

The paper constructs a genome-scale transcriptional regulatory network of the human placenta using genomic and transcriptomic data, identifying key regulators of preterm birth.

This study compares transcriptomes of in vitro human placental models to bulk placental tissue, finding significant gene expression differences and developing a web tool for model selection.