Vincent C. Luca

This study shows that dual stimulation of CD40 and 41BB pathways using a bi-specific molecule enhances CD8+ T cell expansion in TIL cultures.

This paper develops synthetic Notch agonists (SNAGs) that activate Notch signaling by pulling on mechanosensitive receptors, demonstrating their effectiveness in targeting multiple biomarkers.

This study compares endogenous and synthetic Notch systems to understand why synthetic systems do not require ligand ICD for activation.

The paper describes engineered surrogate R-spondins that enhance Wnt signaling in specific cell types by bypassing natural receptor interactions.