Author

Nitin H. Shirole

Broad InstituteORCID 0000-0002-2579-456XUnclaimed ORCID profile · follow to get notified of new preprints

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Nitin H. Shirole1 paper

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Charles XuiD· 1 shared Eddy SaadiD· 1 shared Hairong WeiiD· 1 shared Hilina B. WoldemichaeliD· 1 shared Jason Robert PitarresiiD· 1 shared Jing LuiD· 1 shared Kei EnomotoiD· 1 shared Laura A. StranskyiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Charles XuORCID

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1 paper

Recent·Most cited

Cancer BiologyNature MedicinePeer-reviewedNov 28, 2025

HIF2-driven PTHrP Causes Cachexia and Hypercalcemia in Kidney Cancer: Treatment with HIF2 Inhibitors

Muhannad Abu‐Remaileh, Laura A. Stransky, Nikita Bhalerao…·William G. Kaelin

This study identifies HIF2-driven PTHrP as a cause of cachexia and hypercalcemia in kidney cancer and shows that HIF2 inhibitors can alleviate these symptoms.

14 citationstop 3%

humanbulk RNA-seq

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