Charles Xu

Endocytome profiling uncovers cell-surface protein dynamics underlying neuronal connectivity

The paper introduces endocytome profiling to map cell-surface protein dynamics in developing olfactory receptor neurons, revealing how endocytosis regulates axon pruning and targeting.

HIF2-driven PTHrP Causes Cachexia and Hypercalcemia in Kidney Cancer: Treatment with HIF2 Inhibitors

This study identifies HIF2-driven PTHrP as a cause of cachexia and hypercalcemia in kidney cancer and shows that HIF2 inhibitors can alleviate these symptoms.

Cell-death induced immune response and coagulopathy promote cachexia in Drosophila

This study identifies coagulation and immune factors secreted by Drosophila gut tumors that contribute to cachexia via NFκB and JNK pathways.

Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells

This paper introduces LOV-Turbo, a light-regulated proximity labeling tool that enhances spatial and temporal control of proteomic mapping in living cells.