Benjamin R. Topacio

This study identifies a unique docking interface on cyclin D that binds Rb, a key cell cycle regulator, and shows that targeting this interface can inhibit cell proliferation.

The paper identifies CDK2 substrates in mouse ESCs, revealing HMCES phosphorylation's role in AP-site repair and ESC proliferation.

The paper shows E2F1 induces cell-cycle reentry without changing chromatin accessibility by using pre-existing regulatory elements.

This paper proposes a customized CycleGAN to enhance cell segmentation with limited annotated data, showing improved performance over conventional methods.

This paper shows that CRISPRa activation of two endogenous regulatory elements can self-organize ESCs into embryo-like structures with spatial and molecular features similar to pre-gastrulation mouse embryos.