Jürgen Tuvikene

Identification and inhibition of the Cyclin D Rb-docking interface that drives cell division

This study identifies a unique docking interface on cyclin D that binds Rb, a key cell cycle regulator, and shows that targeting this interface can inhibit cell proliferation.

Direct Mapping of CDK2 Substrates in Embryonic Stem Cells Uncovers an AP-Site Repair Mechanism via HMCES Phosphorylation

The paper identifies CDK2 substrates in mouse ESCs, revealing HMCES phosphorylation's role in AP-site repair and ESC proliferation.

Intronic enhancer region governs transcript-specific BDNF expression in neurons

The paper identifies an intronic enhancer region in the BDNF gene that regulates transcript-specific expression in neurons through an E-box element linked to pro-neural transcription factors.

Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of synaptic proteome

This study shows that the Drosophila orthologue of TCF4, Daughterless, is essential for associative learning and synaptic protein maintenance, with implications for modeling human intellectual disabilities.