Author

Massimiliano Manzo

University of Basel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:simulation· 1

Frequent Co-Authors

Amedeo CaflischiD· 1 shared Benedetto GrimaldiiD· 1 shared Cheryl A. HawkesiD· 1 shared Elena JachettiiD· 1 shared Francesco CreaiD· 1 shared Ilaria AlborelliiD· 1 shared Ino D. KaremakeriD· 1 shared Ioana Mariuca IlieiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Amedeo CaflischORCID

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2 papers

Recent·Most cited

EZH2 inhibition enhances the activity of platinum chemotherapy in aggressive variant prostate cancer

Maryam Latarani, Perla Pucci, Mark Eccleston, Massimiliano Manzo, Priyadarsini Gangadharannambiar, Irene Fischetti, Ilaria Alborelli, Vera Mongiardini, Namra Mahmood, Mario Paolo Colombo, Benedetto Grimaldi, Sushilaben H. Rigas, Shusuke Akamatsu, Cheryl A. Hawkes, Yuzhuo Z. Wang, , Francesco Crea

This study shows that EZH2 inhibition enhances platinum chemotherapy effectiveness in aggressive variant prostate cancer by reducing H3K27me3 and modulating DNA repair and apoptosis pathways.

Epigenomics · Jan 29, 2025Peer-reviewedPharmacology & Toxicology

Flanking sequence preference modulates de novo DNA methylation in the mouse genome

Izaskun Mallona, Ioana Mariuca Ilie, Ino D. Karemaker, Stefan Butz, Massimiliano Manzo, Amedeo Caflisch, Tuncay Baubec

The paper identifies sequence preferences for de novo DNA methylation by DNMT3A and DNMT3B in mouse stem cells, showing structural basis for context-specific methylation.

Nucleic Acids Research · Nov 16, 2020Peer-reviewedMolecular Biology