Haley M. Amemiya

This study shows DNA methylation in E. coli does not alter global chromatin structure but affects specific gene expression changes indirectly.

The paper uses IPOD-HR to globally map protein-DNA interactions in E. coli, revealing dynamic transcription factor occupancy and stable nucleoid factor domains, and develops computational models for transcription factor specificity.

The paper shows that reducing rDNA copy number in S. cerevisiae changes its replication timing, delays genome replication, and links rDNA to cell cycle control via Cdc14p sequestration.