Elizabeth X. Kwan

The paper investigates rDNA instability in aging yeast, identifying new forms of instability beyond ERCs that contribute to lifespan variability.

The paper investigates how rDNA copy number variation affects yeast fitness under different environmental conditions and finds that higher copy numbers improve fitness in stress conditions.

The paper compares replication origin activation in two yeast strains under HU stress, identifying Rad53-dependent origins and showing differences in origin dynamics and checkpoint control.

The paper shows that reducing rDNA copy number in S. cerevisiae changes its replication timing, delays genome replication, and links rDNA to cell cycle control via Cdc14p sequestration.

This study shows that Sld2 and Sld3 abundance primarily affect origin efficiency in yeast replication, not firing time, using auxin-induced degradation.

This study edits rDNA replication origins in yeast using CRISPR/Cas9, revealing growth and lifespan consequences of such modifications.