Chiara Tocco

This study chemically induces senescence in human microglia-like cells and shows they adopt a pro-inflammatory phenotype with reduced phagocytic and calcium activity.

The paper shows that Nr2f1 gene expression in postmitotic neurons controls corticopontine topographic mapping, while its expression in progenitor cells affects the ratio of corticopontine to corticospinal fibers.

This study shows that Nr2f1 regulates neuronal activity and morphology in the developing somatosensory cortex, impacting network synchronization and excitability.