Tamar Sapir

Intelliwaste uses 13C-labeled metabolites and NMR to profile carbon metabolism in stem cells and model neuropathology, revealing metabolic differences in LIS1 mutants.

This study shows that NDE1 loss disrupts neural progenitor identity and forebrain patterning, leading to microcephaly through altered ERK signaling and regional identity shifts.

This study shows that LIS1 mutations in brain organoids lead to increased tissue stiffness and altered ECM structure, with a computational model predicting mechanical changes.