Bozena Kaminska

This study shows hypoxia alters myeloid cell functions in glioblastoma by changing gene expression and chromatin accessibility, affecting immune cell markers and transcription factor regulation.

The paper integrates spatial transcriptomics with immunofluorescence to study astrocyte heterogeneity and function in glioblastomas, revealing spatial distribution and interactions within the tumor microenvironment.

The paper studies repopulated microglia in young and old mice using scRNA-seq and other methods, finding they originate from progenitors, reconstitute functional clusters, and show increased inflammation and distinct morphology in aging.

This study shows that an integrin-blocking peptide enhances anti-PD-1 therapy in gliomas by reversing immunosuppression and restoring an inflammatory tumor microenvironment.

The paper shows SorLA restricts TNFα release from microglia, reducing their anti-tumor response and promoting glioma growth.