Jennifer L. Fish

This study investigates the etiology of craniofacial and cardiac malformations in a mouse model of SF3B4-related syndromes, identifying gene expression and splicing changes linked to developmental defects.

This study shows that Fgf8 regulates the segmentation of the first pharyngeal arch by mediating interactions between the first pharyngeal pouch and cleft.

This study shows that reduced Fgf8 dosage causes asymmetric jaw development in mice, with left-side defects more severe than right-side, and links these asymmetries to heart development.

The paper identifies Gas1 as a key mediator of species-specific jaw size variation through NCM-mediated SHH signaling regulation.

This study shows that EFTUD2 mutations cause mis-splicing of Mdm2, leading to increased P53 activity and craniofacial defects, which can be mitigated by P53 inhibitors.

This study investigates Satb2's role in pre-osteoblast proliferation and nuclear integrity, finding it regulates cell cycle progression and DNA replication, with potential implications for skeletal defects and cancer.