Fjodor Merkuri

This study shows lactate epigenetically regulates cell states in H3K27M diffuse midline gliomas by modifying histones, and targeting CBP/p300 reduces tumor heterogeneity and improves preclinical outcomes.

This study investigates the etiology of craniofacial and cardiac malformations in a mouse model of SF3B4-related syndromes, identifying gene expression and splicing changes linked to developmental defects.

This study shows that EFTUD2 mutations cause mis-splicing of Mdm2, leading to increased P53 activity and craniofacial defects, which can be mitigated by P53 inhibitors.

This study investigates Satb2's role in pre-osteoblast proliferation and nuclear integrity, finding it regulates cell cycle progression and DNA replication, with potential implications for skeletal defects and cancer.