Neurosciencenpj Parkinson s DiseasePeer-reviewed
Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons
Gurvir S. Virdi, Minee L. Choi, James R. Evans…·Sonia Gandhi
This study uses hiPSCs with SNCA mutations to identify early molecular events in synucleinopathy, showing protein aggregation precedes functional impairments in midbrain dopaminergic neurons.