Author

Daniela Melandri

UCL Queen Square Institute of NeurologyORCID 0000-0002-3630-5143Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Sonia GandhiiD· 4 shared James R. EvansiD· 3 shared Andrey Y. AbramoviD· 2 shared Benjamin J. O’CallaghaniD· 2 shared Dilan S. AthaudaiD· 2 shared Gurvir S. VirdiiD· 2 shared Hélène Plun‐FavreauiD· 2 shared Marc P. M. SoutariD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Sonia GandhiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NeuroscienceAutophagy ReportsPeer-reviewedJun 12, 2026

Glucose concentration of neuronal media formulations influences PINK1-dependent mitophagy in human iNeurons

Benjamin J. O’Callaghan, Daniela Melandri, Darija Šoltić…·Hélène Plun‐Favreau

This study shows that glucose levels in neuronal culture media affect PINK1-dependent mitophagy in human iNeurons, with BrainPhys medium reducing mitophagy compared to N2B27.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

Neurosciencenpj Parkinson s DiseasePeer-reviewedNov 24, 2022

Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons

Gurvir S. Virdi, Minee L. Choi, James R. Evans…·Sonia Gandhi

This study uses hiPSCs with SNCA mutations to identify early molecular events in synucleinopathy, showing protein aggregation precedes functional impairments in midbrain dopaminergic neurons.

66 citationstop 2%

humanscRNA-seq

𝕏 PostBluesky

NeuroscienceBrainPeer-reviewedSep 7, 2022

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at Chr16q11.2 and on the MAPT H1 allele

Marc P. M. Soutar, Daniela Melandri, Benjamin J. O’Callaghan…·Hélène Plun‐Favreau

The paper identifies KAT8 and KANSL1 as regulators of PINK1-mitophagy linked to Parkinson's disease risk, suggesting a novel pathway for therapeutic targeting.

60 citationstop 2%

humanwhole-genome sequencing

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 8, 2020

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson's disease.

Gurvir S. Virdi, Minee L. Choi, Zhi Yao…·Sonia Gandhi

This paper develops a method to generate highly enriched midbrain dopaminergic neurons from hiPSCs, which model Parkinson's disease features like synucleinopathy and mitochondrial dysfunction.

DOI 10.1101/2020.09.08.287797

humanscRNA-seq

𝕏 PostBluesky