Andrey Y. Abramov

Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons

This study uses hiPSCs with SNCA mutations to identify early molecular events in synucleinopathy, showing protein aggregation precedes functional impairments in midbrain dopaminergic neurons.

Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity

The paper tracks α-synuclein conformational changes in neurons and shows mitochondrial involvement in oligomerization and toxicity.

Astrocyte mitochondria produce nitric oxide from nitrite to modulate cerebral blood flow during brain hypoxia

The paper shows astrocytes produce nitric oxide from nitrite via mitochondrial sulfite oxidase during hypoxia, modulating cerebral blood flow.

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synuclein

The paper identifies 38 genes regulating a-synuclein cell-to-cell transfer using an siRNA screen and shows genetic overlap with Parkinson's disease.

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson's disease.

This paper develops a method to generate highly enriched midbrain dopaminergic neurons from hiPSCs, which model Parkinson's disease features like synucleinopathy and mitochondrial dysfunction.

Mitochondrial impairment and rescue in riboflavin responsive neuropathy

This study identifies RFVT gene mutations in BVVLS, shows mitochondrial dysfunction, and demonstrates therapeutic potential with riboflavin esters.