Tumoral hypoxic extracellular vesicles foster a protective microenvironment in triple-negative breast cancer
Bianca Cruz Pachane, Pedro Henrique Teixeira Bottaro, Aline Maria Machado, Cynthia Aparecida de Castro, G. Gómez Guerra, Larissa Thabata Gozzer, Marina Mantellatto Grigoli, Arthur Deponte Zutião, Angelina Maria Fuzer, Márcia R. Cominetti, Wanessa Fernanda Altei, Heloísa Sobreiro Selistre-de-Araújo
This study investigates how hypoxic extracellular vesicles from triple-negative breast cancer cells influence the tumor microenvironment by promoting M2-like macrophages and pro-tumoral signaling.
Journal of Extracellular Biology · Sep 1, 2025Peer-reviewedCancer Biology