Heloísa Sobreiro Selistre-de-Araújo

This study investigates how hypoxic extracellular vesicles from triple-negative breast cancer cells influence the tumor microenvironment by promoting M2-like macrophages and pro-tumoral signaling.

In validated multicenter replications, 20 to 44% of 45 published Brazilian MTT, RT-PCR and elevated plus maze experiments replicated, depending on criterion; replication effects were usually smaller.

This study investigates how extracellular vesicles adhere to different surfaces and shows that borosilicate glass coverslips can effectively immobilize EVs for imaging techniques.

The paper investigates how extracellular vesicles interact with B cells in nonhuman primates and humans, showing uptake via endocytosis and membrane fusion, and highlights potential strategies to modulate EV-B cell interactions.