Author

Appu Kumar Singh

Indian Institute of Technology KanpurORCID 0000-0002-2685-4018Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Mansi SharmaiD· 2 shared SRISTI NANDA· 2 shared Ankur ChattopadhyayiD· 1 shared Dabbu Kumar JaijyaniD· 1 shared Kirill A. MartemyanoviD· 1 shared KV Nageswar· 1 shared Montserrat SamsóiD· 1 shared Nishtha Varshney· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Mansi SharmaORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintFeb 18, 2026

Unique pore architecture underlies constitutive gating of human retinalTRPM1

Mansi Sharma, KV Nageswar, Vikesh Kumar…·Appu Kumar Singh

The paper reports the first cryo-EM structure of human TRPM1 in a conducting state, revealing an unexpected domain-swapped pore architecture and constitutive gating mechanism.

DOI 10.64898/2026.02.18.706614

humancryo-EM

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BiochemistrybioRxivPreprintSep 24, 2024

Cryo-EM structures of human GPR155 elucidate its regulatory and transport mechanisms

Mansi Sharma, Dabbu Kumar Jaijyan, SRISTI NANDA…·Appu Kumar Singh

This study presents cryo-EM structures of human GPR155, revealing its transporter and GPCR domains' conformations and cholesterol-dependent dimerization.

6 citations

humancryo-EM

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