Montserrat Samsó

This study shows that high PVC burden causes inflammation and fibrosis, leading to adverse cardiac remodeling and increased risk of heart failure and sudden cardiac death.

This study uses cryo-EM to visualize how dantrolene inhibits the Y522S RyR1 mutant, revealing its binding site and mechanism of action in preventing malignant hyperthermia.

This study presents cryo-EM structures of human GPR155, revealing its transporter and GPCR domains' conformations and cholesterol-dependent dimerization.

The paper determines cryo-EM structures of RyR1 with Mg2+ and identifies multiple Mg2+ binding sites, revealing its inhibitory mechanism and interaction with gating helices.