Kirill A. Martemyanov

Auto-SMART: a web-based platform for repair-template design for CRISPR/Cas9 homology-directed editing

Auto-SMART automates the design of CRISPR/Cas9 repair templates, enabling efficient genome editing by optimizing guide RNA selection and donor template construction.

TRACR: an anterograde transneuronal tracing system for genetic access across synapses and longitudinal circuit analysis

TRACR is a transneuronal tracing system that uses synthetic Notch technology to label postsynaptic neurons and analyze circuit connectivity in the mouse visual system.

Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response

This study uses optoretinography in R9AP-bradyopsia patients to show that G-protein signaling is essential for the human cone elongation response.

Unique pore architecture underlies constitutive gating of human retinalTRPM1

The paper reports the first cryo-EM structure of human TRPM1 in a conducting state, revealing an unexpected domain-swapped pore architecture and constitutive gating mechanism.

Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma

This paper identifies hydralazine as an inhibitor of cysteamine dioxygenase (ADO), showing its role in treating preeclampsia and inducing senescence in glioblastoma.

DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides

This paper introduces DeFrNDs, detergent-free nanodiscs made with engineered membrane scaffold peptides, enabling high-resolution structural analysis of membrane proteins in native lipid environments.

Retinal circuits driving a non-image forming visual behavior

This study identifies the retinal circuits responsible for the pupillary light response (PLR) in mice, showing that rods, not cones, drive the PLR across light intensities.