Virpi Talman

Patient-Derived hiPSC-Cardiomyocytes and Engineered Heart Tissues Reveal Distinct Functional Phenotypes in Inherited Cardiomyopathies

This study uses patient-derived hiPSC-cardiomyocytes and engineered heart tissues to compare functional and molecular phenotypes in HCM and DCM, revealing genotype-specific responses to stimuli.

The novel SCN5A-P1891A mutation is associated with left ventricular hypertrabeculation and links Nav1.5 to cardiomyocyte proliferation and disrupted 3D cardiac tissue formation

This study identifies a novel SCN5A mutation linked to left ventricular hypertrabeculation and shows its impact on cardiomyocyte proliferation and 3D cardiac tissue formation.

Molecular atlas of postnatal mouse heart development

This study provides a molecular atlas of postnatal mouse heart development by integrating transcriptomics, proteomics, and metabolomics data to identify metabolism-related mechanisms linked to the loss of cardiac regeneration.