Author

Mika J. Välimäki

University of HelsinkiORCID 0000-0002-9687-8197Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Aino PeuraiD· 1 shared Andrei GogaiD· 1 shared Anni I. NiemineniD· 1 shared Antti O. HiltuneniD· 1 shared Bina PrajapatiiD· 1 shared Christopher Benjamin JacksoniD· 1 shared Daniel NicoriciiD· 1 shared Hanna Ala-HongistoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Aino PeuraORCID

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2 papers

Recent·Most cited

Patient-Derived hiPSC-Cardiomyocytes and Engineered Heart Tissues Reveal Distinct Functional Phenotypes in Inherited Cardiomyopathies

Saana Pohjavaara, Qasim A. Majid, Leo Huttunen, Katriina Aalto‐Setälä, Heikki J Ruskoaho, Mika J. Välimäki, Sini M. Kinnunen, Virpi Talman

This study uses patient-derived hiPSC-cardiomyocytes and engineered heart tissues to compare functional and molecular phenotypes in HCM and DCM, revealing genotype-specific responses to stimuli.

bioRxiv · Sep 4, 2026 · PreprintPharmacology & Toxicology

Complex I Drives Glutamine-Dependent TCA Cycle to Support Viability of MYChigh Breast Cancer Cells

Johanna M. Anttila, Mariel Savelius, Juhi Somani, Daniel Nicorici, Pauliina Munne, Linda Id, Aino Peura, Antti O. Hiltunen, July Aung, Ryan Awadhpersad, Bina Prajapati, Martina Peltonen, Hanna Ala-Hongisto, Prson Gautam, Mika J. Välimäki, , Juha T. Klefström

This study identifies enhanced mitochondrial respiration and glutamine-dependent TCA cycle as vulnerabilities in MYChigh breast cancer cells, showing synthetic lethality with complex I inhibitors.

bioRxiv · May 27, 2025 · PreprintCancer Biology