Xiaonan Liu

This study identifies β4-integrins as critical for maintaining nuclear mechanics and integrity in prostate cancer, linking cell-ECM adhesion to genome stability and patient survival.

The paper identifies a phosphorylation switch in PAGE4 as a key mechanism in MED12-mutant fibroid pathogenesis, revealing its role in rewiring the interactome and transcriptional machinery.

The paper compares plasma protein enrichment methods, finding MagNet significantly increases protein identifications and enables cost-effective, high-throughput LC-MS proteomics.

This study identifies a novel SCN5A mutation linked to left ventricular hypertrabeculation and shows its impact on cardiomyocyte proliferation and 3D cardiac tissue formation.

The paper maps the interactome and substrates of human receptor tyrosine kinases using AP-MS, BioID, and kinase assays, revealing interactions and functions of both well-known and understudied RTKs.

The paper develops an integrated approach combining AP-MS and BioID to map protein interactions and molecular contexts across the human proteome.