Katriina Aalto‐Setälä

This study uses patient-derived hiPSC-cardiomyocytes and engineered heart tissues to compare functional and molecular phenotypes in HCM and DCM, revealing genotype-specific responses to stimuli.

This paper introduces a scalable 3D liver model using hiPSC-derived organoids to predict drug toxicity, showing comparable functionality to primary hepatocytes.

The paper compares the response of celiac disease and healthy control iPSC-derived small intestinal epithelial cells to cytokine stimuli, finding attenuated responses in celiac disease cells.

This study identifies 1,242 novel genetic variants and 31 novel genes associated with frailty through genome-wide association and proteomics integration.

This study identifies a novel SCN5A mutation linked to left ventricular hypertrabeculation and shows its impact on cardiomyocyte proliferation and 3D cardiac tissue formation.

This study conducts a genome-wide meta-analysis across three biobanks to identify new genetic loci associated with lumbar disc herniation, expanding the known genetic landscape.

Finnish-enriched low-frequency variants, often coding, underlie many GWAS signals across 1,932 register endpoints in 218,792 Finns; a 15-disease meta-analysis with Estonian and UK biobanks adds 30 unreported associations.