Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire
Pilar X. Altman, Gabriel Ozorowski, Robyn L. Stanfield, Jeremy K. Haakenson, Michael Appel, Mara Parren, Wen-Hsin Lee, Huldah Sang, Jordan L. Woehl, Karen L. Saye-Francisco, Leigh M. Sewall, Collin Joyce, Ge Song, Katelyn Porter, Elise Landais, , Devin Sok
This study immunized cows with HIV Env trimers to generate broadly neutralizing antibodies targeting the V2-apex, revealing ultralong CDRH3 antibodies outcompete shorter ones in the response.
PLoS Pathogens · Sep 9, 2024Peer-reviewedImmunology