Elisabet M. Englund

This study uses spatial transcriptomics to analyze lung tissue from fatal COVID-19 cases, identifying cellular and molecular changes during disease progression.

The paper shows that DNA methylation and the HUSH-MORC2 complex independently regulate repeat elements in human neural progenitor cells, with MORC2 binding increasing in demethylated regions.

The paper shows that sequencing ambiguity between GBA1 and its pseudogene GBAP1 affects transcriptomic analysis, revealing non-lysosomal functions in the brain and widespread annotation inaccuracies.

This study shows L1 retrotransposons contribute to human brain transcriptome complexity and functional diversification through cell-type specific transcripts and regulatory RNAs.

This paper investigates how histological features like cell density and structure anisotropy explain variations in diffusion MRI metrics MD and FAIP in meningioma tumors, finding that cell density explains variability across but not within tumors.

The paper uses snRNA-seq to analyze TBI brain tissue, finding oligodendroglia activate endogenous retroviruses, linking them to neuroinflammation.

This study shows plasma neurofilament light chain levels correlate with diffusion tensor imaging metrics in frontotemporal dementia, indicating a link between blood biomarkers and white matter degeneration.

This study identifies galectin-3 as a novel endogenous TREM2 ligand that regulates microglial activation and Aβ fibrillation in Alzheimer’s disease.