Yogita Sharma

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease

The paper investigates TE transcription in Parkinson's disease brains, finding region- and cell-type-specific TE activation linked to an interferon response in microglia and neurons.

Human brain cell-type-specific aging clocks based on single-nuclei transcriptomics

The paper develops cell-type-specific transcriptomic aging clocks using single-nuclei RNA sequencing data from human prefrontal cortex tissue, showing distinct aging patterns across cell types.

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

This study shows that L1 retrotransposons influence human pluripotency exit and early brain development through their expression and derived transcripts.

Efficient generation of human oligodendrocyte grafts that restore myelin in adult human brain tissue

This study develops a method to efficiently generate human oligodendrocytes from induced pluripotent stem cells, which can form functional myelinating grafts in adult human brain tissue.

L1 retrotransposons drive human neuronal transcriptome complexity and functional diversification

This study shows L1 retrotransposons contribute to human brain transcriptome complexity and functional diversification through cell-type specific transcripts and regulatory RNAs.

Single-cell transcriptomics of resected human traumatic brain injury tissues reveals acute activation of endogenous retroviruses in oligodendroglia

The paper uses snRNA-seq to analyze TBI brain tissue, finding oligodendroglia activate endogenous retroviruses, linking them to neuroinflammation.

Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson's disease

This study generates patient-derived induced dopaminergic neurons to show age-related autophagy impairments and alpha-synuclein accumulation in Parkinson's disease.

Distinct sub-cellular autophagy impairments occur independently of protein aggregation in induced neurons from patients with Huntington's disease

This study shows that induced neurons from Huntington's disease patients have impaired autophagy in neurites, independent of protein aggregation, and that HTT is critical for neuronal autophagy.

Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures

The paper uses single-cell RNA sequencing to profile fetal human midbrain dopamine neurons at different developmental stages and establishes a 3D culture system to study their functional maturation.

A human-specific structural variation at the ZNF558 locus controls a gene regulatory network during forebrain development

The paper identifies a human-specific structural variation at the ZNF558 locus that regulates a gene network involved in forebrain development by controlling SPATA18 expression through a VNTR contraction.

Activation of endogenous retroviruses during brain development causes neuroinflammation

This study shows that activation of endogenous retroviruses during brain development leads to neuroinflammation in adult mice.

Single Cell Gene Expression Analysis Reveals Human Stem Cell-Derived Graft Composition in a Cell Therapy Model of Parkinson’s Disease

The paper uses scRNA-seq to analyze graft composition in a Parkinson’s disease cell therapy model, revealing differences between human stem cell-derived and fetal tissue grafts.

LINE-2 transposable elements are a source for functional human microRNAs and target sites.

The paper identifies LINE-2-derived microRNAs and their target sites in human tissues, showing their role in regulating gene expression and their disruption in glioblastoma.